Cavity-causing bacteria
34%lower
Down by about a third on average.
Average saliva score, measured with the SillHa Oral Wellness System (ARKRAY). p = 0.045.
the technology inside smart3®
FoodBIOME® EXPLAINEDA food-based delivery system, developed and made under one roof.
WHAT IS FoodBIOME®?
Most supplements put ingredients in a pill. FoodBIOME® builds them into food for your oral and gut microbiome.
FoodBIOME® is a patent-pending structured matrix of lipids, antioxidants and biotics, designed so that the food itself does part of the work. It’s the foundation of every Smart3® product, and it’s why taking Smart3® feels like a treat rather than a task.
the BASICS
Fillers & inactive ingredients
Binders, bulking agents and flow aids, often a white powder. They’re there for the pill, not for you.
Lipids that carry
A structured base of healthy fats holds the formula together and carries it through digestion.
Antioxidants that protect
They help protect the formula’s ingredients and support your body’s everyday defenses.*
Biotics that feed
They give the beneficial microbes in your gut something to work with.*
Active ingredients
POWERED BY FoodBIOME®: A DIFFERENT APPROACH TO DELIVERY
Your microbiome doesn’t start in your gut. It starts in your mouth. FoodBIOME® is designed to work along the whole route.
Every supplement needs a carrier to get its active ingredients into your body. In a capsule, that’s a shell and filler. In a liposomal gel, it’s tiny bubbles of phospholipids wrapped around each ingredient. FoodBIOME® takes a different approach: the carrier is a food. Its lipids, antioxidants and biotics hold the formula together and carry it through digestion, and they’re part of what you’re eating, with benefits of their own.* That’s what “Powered by FoodBIOME®” means on every Smart3® product.
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Stop 1 · First contact
In your mouth
FoodBIOME® doesn’t just pass through. It stays in the mouth longer instead of being swallowed in a second, and mixes with saliva.
It reaches the 700+ species of microbes in the mouth, so the mouth is the first place it meets your microbiome. Then it carries on.
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Stop 2 · In transit
Through digestion
FoodBIOME® travels as food, not as a pill. Its lipid structure is designed to hold the formula together and carry it through your stomach.
Along the way, its antioxidants help protect the formula’s ingredients. Then it moves on to your gut.
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Stop 3 · Destination
In your gut
The biotics and antioxidants arrive in your gut, home to most of your microbiome. There, the biotics give your beneficial microbes something to work with.
Together, they’re designed to support a balanced gut microbiome.*
Research on the oral and gut microbiome
The FoodBIOME® platform has been explored through pilot research evaluating oral and gut microbiome related outcomes to study oral-first, gut-second supporting benefits from a single serving.
This simple difference reflects a new way of thinking about food, not just as nutrition, but as an intentional daily experience.
What Happened In The Mouth
Oral Pilot • 30 days
How the pilot was run
- Duration
- 30 days
- Daily amount
- 5 g of FoodBIOME®
- Sample
- Saliva, at the start and at the end
- Testing
- SillHa Oral Wellness System (ARKRAY)
- Type of study
- Exploratory human pilot
What this means
FoodBIOME® supports oral microbiome balance and supports a reduction in cavity-causing bacteria levels.*
This pilot was designed to look for early signals, not to replace a large clinical trial.
What Happened In The Gut
GUT Pilot • 40 days
Gut microbiome makeup
Measurably shifted
After 40 days, the overall mix of gut bacteria had changed.
Increased
- Akkermansia muciniphila
- Parabacteroides distasonis
Decreased
- Clostridium bolteae
- Morganella morganii
- Stool pH
- Lower by about 1 to 1.5 units in most participants
- Bacterial richness
- 154.6 to 220.2 (not reported as statistically significant)
Microbiome makeup compared before and after at the genus level (PERMANOVA). p = 0.036.
How the pilot was run
- Duration
- 40 days
- Daily amount
- 5 g of FoodBIOME®
- Sample
- Stool, at the start and at the end
- Analysis
- pH, gut bacteria and fungi
- Type of study
- Exploratory human pilot
What this means
FoodBIOME® supports gut microbiome modulation.*
This pilot was designed to look for early signals, not to replace a large clinical trial.
How IT's MADE
FROM LAB TO FINISHED PRODUCT, UNDER ONE ROOF
Many supplement brands design a label and outsource the rest. We do it all ourselves: research, formulation, manufacturing and testing happen in the same facility, by the same team.
A facility free of the 9 major food allergens
Our facility does not handle any of the nine major food allergens identified by the FDA: milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soybeans and sesame. They aren’t in our formulas, and they never come through our doors, so there’s no shared equipment with allergen-containing products.
One facility · One team
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Step 1
We develop it
Our own R&D team created FoodBIOME® and keeps refining it in-house.
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Step 2
We formulate it
Every Smart3® formula is built on the same FoodBIOME® composition.
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Step 3
We make it
In our own GMP-compliant facility. Nothing is handed to a contract manufacturer.
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Step 4
We test it
Every batch comes with a Certificate of Analysis, verified by independent labs.
What that means for you: the FoodBIOME® composition that was studied, made the same way every time.
- GMP-compliant
- Third-party tested
- CoA for every batch
- Made in the USA
Frequently asked questions
Is FoodBIOME® a product or an ingredient?
It can be both. FoodBIOME® is the common base that every Smart3® product is built on: each formula adds its own active ingredients to it.
But its flavor and texture make it a great finished product on its own. You asked, we listened: Naked Nature® is FoodBIOME® to enjoy just as it is.
What is the oral and gut microbiome?
Your microbiome is the community of microbes, mostly bacteria, that live in and on your body. The oral microbiome lives in your mouth, and the gut microbiome lives in your digestive tract.
The two are connected: everything you eat passes through your mouth on its way to your gut. Researchers call this link the oral–gut axis.
How does FoodBIOME® support the oral and gut microbiome?
Because you chew FoodBIOME® as food instead of swallowing a capsule, it meets your oral microbiome from the very first bite. It then continues to your gut, where its biotics give your beneficial microbes something to work with.*
In two human pilot studies, FoodBIOME® supported oral microbiome balance and gut microbiome modulation.* See what the studies found.
Is FoodBIOME® liposomal?
No. Liposomes are phospholipid bubbles that carry an ingredient. FoodBIOME® is a structured food in which the lipids, antioxidants and biotics are all part of the formula.
What are biotics?
“Biotics” is the umbrella term for the ingredients that support the microbes living in your body, especially in your gut. There are three main kinds:
- Prebiotics are food for your beneficial microbes, usually certain fibers and plant compounds.
- Probiotics are live beneficial microbes.
- Postbiotics are beneficial compounds made by microbes, or inactive microbes themselves.
The biotics in FoodBIOME® give the beneficial microbes in your gut something to work with.*
Is it patented?
The FoodBIOME® composition is patent-pending.
What does “Powered by FoodBIOME®” mean?
It means the product is built on FoodBIOME®, a patent-pending food base made of lipids, antioxidants and biotics. Instead of packing active ingredients into a capsule with filler, each Smart3® product adds its active ingredients to FoodBIOME®.
You get the benefits of FoodBIOME® itself,* plus those of the active ingredients, in a food you enjoy. FoodBIOME® is developed, made and tested in our own facility, and it’s the same composition that was evaluated in two human pilot studies.
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